Five Phases
To
Production
Minos is being built in five phases, starting with hyperparameter optimization of proven tools and progressing toward fully custom algorithms, consensus AI, and production-grade genomic services.
Each phase validates and expands the infrastructure, ensuring scientific rigor while enabling decentralized innovation at every step.
Phase Overview
05 PHASESHyperparameter Optimization
Optimize configs for established variant callers
Custom Genotyping Algorithms
Miners submit their own variant calling code
Broader Variant Spectrum
SVs, CNVs, HLA, and difficult regions
Consensus AI
Meta-caller from top miner outputs
Production Deployment
Versioned containers, clinical reporting
Phase Details
Hyperparameter Optimization
ACTIVEMiners optimize hyperparameter configurations for four established variant calling tools: GATK HaplotypeCaller, DeepVariant, bcftools, and freebayes. This phase validates the full infrastructure: challenge generation, HelixForge injection, hap.py scoring, EMA tracking, and Winner-Take-All weight distribution.
Custom Genotyping Algorithms
NEXTMiners submit novel variant calling algorithms as executable code. This unlocks algorithmic innovation: neural network callers, hybrid methods, and region-specialized algorithms. Code executes in sandboxed Docker containers.
Broader Variant Spectrum
PLANNEDThe competition expands beyond small variants to include structural variants, copy number variants, and clinically important regions like HLA genes. Scoring evolves to handle these more complex variant types that other pipelines omit due to their complexity.
Consensus AI
PLANNEDAggregate the best-performing miner outputs into a unified consensus model that combines the strengths of diverse approaches. This meta-caller is expected to exceed the accuracy of any individual pipeline.
Production Deployment
VISIONShip the consensus caller as a production-grade service: versioned Docker images, automatic updates from subnet learnings, clinical-friendly reporting, and state-of-the-art accuracy tracking.